Trimetazidine hydrochloride controlled release tablets are used to treat angina pectoris in adults. Trimetazidine works by:

• 1. Improving the heart’s energy metabolism
• 2. Reducing the heart’s oxygen demand
• 3. Increasing the heart’s tolerance to stress

Specifically, trimetazidine is used to:

• 1. Treat chronic stable angina
• 2. Reduce the frequency and severity of angina attacks
• 3. Improve exercise tolerance
• 4. Reduce the need for other anti-anginal medications

Trimetazidine is often used in combination with other medications, such as beta blockers, calcium channel blockers, or nitrates, to manage angina. It’s important to note that trimetazidine is not used to treat acute angina attacks or other conditions, such as high blood pressure or heart failure.

Trimetazidine has a unique mechanism of action, which sets it apart from other anti-anginal medications. It works by inhibiting the enzyme long-chain 3-ketoacyl-CoA thiolase (3-KAT), which plays a key role in the heart’s energy metabolism. By inhibiting 3-KAT, trimetazidine helps the heart to use energy more efficiently, reducing the strain on the heart and alleviating angina symptoms.